We propose 2 methods to decipher the reaction changes during a metabolic transient state, using measurements of metabolic concentrations.

TOTORO: TOpological analysis of Transient metabOlic RespOnse

Totoro uses qualitative measurement of concentrations in two steady-states to infer the reaction changes that lead to differences in metabolite pools in both conditions. The software uses an ASP formulation to perform hyperarc selection in the directed hypergraph representation of a metabolic network. In the release are included the pre-processing and post-processing steps. After the post-processing step, the solutions can be visualized using href="http://dinghy.gforge.inria.fr/"> DINGHY

Release Beta

Totoro Release Beta (2016-12-04)

Developers:

Louis Duchemin, Alice Julien-Laferrière, Arnaud Mary

KOTOURA: Kantitative analysis Of Transient metabOlic and regUlatory Response And control

Kotoura infers quantitative changes of the reactions using information on measurement of the metabolite concentrations in two steady-states. Kotoura is developed in C++ and uses an IBM solver CPLEX.

Release Beta

Kotoura Release Beta (2016-12-04)

Developers:

Ricardo De Andrade, Alice Julien-Laferrière, Laurent Bulteau